To answer your question I ask you, what is toxic? is it the one that started the subject that is toxic? or is it the person that views the subject that sees it as toxic? the subject only exists because someone created it so it is not toxic or non toxic it simply is.

If you judge that the person that started this subject is toxic because you do not like or agree on something would you be surprised that someone else would eventually do the same to you?

If you see that you are the one that does not like it then you might be onto something, ask yourself

"what is it that i do not like about this?"

seek and you will find the real problem, when you become aware of something and understand it you do not ask yourself questions about it because you already know the answer.

A good example about toxic would be pollution. You exist so you create pollution: breathing and fecal matter bacteria, I could go on, car exhaust, industrial pollution on a large scale. but guess what, it is human. Is it needed? yes it is, for living in this world, do you always have to agree? no you have the choice. Is there some abuse that does not justify this large scale pollution? example: something illogical like dumping toxic waste in the water at the place of dumping it at a waste disposal place, just for the boss company profit margin. it is easy to complain and judge outside things. it is not as easy to know why you do such things.

Be aware, know and understand it is part of growing.

Every subject on the planet is neutral. In fact there is no reality outside of yourself. We all live in our own individual worlds bumping along together.

Your vibrational state will determine how you view the world, what is toxic or not toxic to you will depend on where your dominant setpoint is. In a way it's as if you're viewing the neutral world through glasses and those glasses act like filters for what you see and feel 'out there'.

If you are in a happy, joyful state everywhere you go in your life you will meet other happy people, your relationships will flow nicely there will be lots of laughter and fun in your life. You are quick to see all the good around you, all the love. You wouldn't need to hide away from 'toxic' people because you wouldn't be able to see anything 'toxic' through your happy, loving glasses.

If you're seeing 'toxic' people and situations all you have to raise your emotional setpoint by focusing only on all the things that make you feel good. Once joy/love is your dominant setpoint you can see the world through your happy glasses. there's no need to hide away from anyone or anything then.

Self-isolation from what one deems toxic will only perpetuate more toxicity, leading to greater isolation and further disconnection from All-There-Is. If spiritual growth/expansion and achievement of unconditional love is part of your preferred soul resonance journey, IN-clusion rather than DIS-clusion will prove a more beneficial path to follow in achieving such.

The vibrational frequency one chooses to be in, or wishes to be in, will not come about or be understood without the unconditional love and awareness of the frequencies one does not wish to be in. Were it not for such frequencies, how would one know what one prefers?

'Is it necessary to give energy and attention to life's physical and metaphysical oneness or can we simply know?'

We do know! :o) Our knowing is intuition and discernment: these are our most beneficial guides. As far as giving energy and attention to life's physical and metaphysical oneness, as we are Masters of Limitation, we love the drama of not knowing and figuring such out in our own way, with limited help.

'Could there be a part of us that is always growing even when we aren't thinking about anything particularly relevant?'

Not 'could' but IS. We are continuously shifting in vibrational frequency via every thought, every desire, every dream, every co-creational physical interaction, etc.